TP53 DRIVES ABSCOPAL EFFECT BY SECRETION OF SENESCENCE-ASSOCIATED MOLECULAR SIGNALS IN NON-SMALL CELL LUNG CANCER

TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer

Abstract Background Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease.However, deeper understanding of the molecular mechanisms underlying the abscopal effect are required to best benefit a larger proportion of patients with metastasis.Several groups including ours, reported the

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Type-B anomaly matching and the 6D (2,0) theory

Abstract We study type-B conformal anomalies associated with 1 2 $$ rac{1}{2} $$ -BPS Coulomb-branch operators in 4D N $$ mathcal{N} $$ = 2 superconformal field theories.When the vacuum preserves the conformal symmetry these anomalies coincide with the two-point function coefficients in the Coulomb-branch chiral ring.They are non-trivial functions

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Single-cell RNA sequencing in juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children, with onset before ECOTRAIL age 16 and lasting for more than 6 weeks.JIA is a highly heterogeneous condition with various consequences for health and quality of life.For some JIA patients, early detection and intervention remain challen

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Redescription and molecular characterization of Placobdella cryptobranchii (Johnson & Klemm, 1977) (Glossiphoniidae, Hirudinida)

Placobdella cryptobranchii (Johnson & Klemm, 1977) was originally described from specimens collected from Ozark Hellbenders Accessories (Cryptobranchus alleganiensis bishopi) from the North Fork of the White River in Missouri, U.S.A.Leeches collected during August 2009 to August 2011 from five localities in Missouri (including the type locality

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